Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema
نویسندگان
چکیده
منابع مشابه
The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema.
OBJECTIVE To demonstrate superiority of ranibizumab 0.5 mg monotherapy or combined with laser over laser alone based on mean average change in best-corrected visual acuity (BCVA) over 12 months in diabetic macular edema (DME). DESIGN A 12-month, randomized, double-masked, multicenter, laser-controlled phase III study. PARTICIPANTS We included 345 patients aged ≥18 years, with type 1 or 2 di...
متن کاملComparison of Therapeutic Efficacy of Intravitreal Bevacizumab plus Macular Laser versus Intravitreal Triamcinolone Acetonide plus Macular Laser in Primary Treatment of Diabetic Macular Edema
To compare the efficacy of intravitreal bevacizumab and macular laser vis-a-vis intravitreal triamcinolone acetonide and macular laser in primary treatment for diabetic macular edema. Randomised, prospective, comparative two-arm, non-interventional study with five time points. 60 eyes of 30 patients with bilateral DME and no previous ocular intervention participated in the study and were random...
متن کاملRanibizumab Monotherapy or Combined with Laser versus Laser Monotherapy for Diabetic Macular Edema: A Meta-Analysis of Randomized Controlled Trials
OBJECTIVE To evaluate the relative efficacy of ranibizumab (RBZ) monotherapy or combined with laser (RBZ + Laser) versus laser monotherapy for the treatment of diabetic macular edema (DME). METHODS A comprehensive literature search using PUBMED, ClinicalTrials.gov, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing RBZ or RBZ + Laser to laser monotherapy in pat...
متن کاملBaseline central macular thickness predicts the need for retreatment with intravitreal triamcinolone plus laser photocoagulation for diabetic macular edema
PURPOSE To identify baseline characteristics that predict the number of treatments with intravitreal triamcinolone acetonide (IVTA) plus laser photocoagulation needed to treat diabetic macular edema over a 2-year period. METHODS Individual data from 42 eyes of 42 participants treated with IVTA plus laser photocoagulation for diabetic macular edema during a prospective, randomized, double-mask...
متن کاملEvaluation of masking study participants to intravitreal injections in a randomized clinical trial.
OBJECTIVE To evaluate the success of masking study participants to treatment allocation using sham intravitreal injections. METHODS Eyes were randomized to receive sham injections plus prompt laser, intravitreal ranibizumab injections plus prompt laser, intravitreal ranibizumab injections plus deferred laser, or intravitreal triamcinolone acetonide injections plus prompt laser up to every 16 ...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2010
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2010.02.031